Bimetallic Palladium/Cobalt Catalysis for Enantioselective Allylic C−H Alkylation via a Transient Chiral Nucleophile Strategy.

An asymmetric allylic C−H functionalization has been developed by making use of transient chiral nucleophiles, as well as bimetallic synergistic catalysis with an achiral Pd0catalyst and a chiral N,N′‐dioxide‐CoIIcomplex. A variety of β‐ketoesters and N‐Boc oxindoles coupled with allylbenzenes and aliphatic terminal alkenes were well tolerated, furnishing the desired allylic alkylation products in high yields (up to 99 %) with excellent regioselectivities and enantioselectivities (up to 99 % ee). [ABSTRACT FROM AUTHOR]