Effet thérapeutique de l'extrait aqueux de Pimpinella anisum L. chez les rats Wistar exposés de manière subchronique à l'imidaclopride. Étude neurocomportementale.

This study was carried out in order to evaluate the therapeutic power of the aqueous extract of Pimpinella anisum L. (EAP) following 28-days exposure to imidacloprid (IMD) in Wistar rats. The results of the open field test represent a significant reduction (P < 0.001) in the number of squares crossed in the intoxicated lot compared to the control lot, which translates translates into a reduction in locomotor activity. In addition, the forced swimming test showed a significant increase (P<0.001) in the immobility time in rats exposed to IMD compared to control and exposed treated rats. Statistical analysis of the data from the Barnes test showed that rats exposed to this pesticide have a significant high number of errors and latency to reach the target hole (P < 0.001) compared to the control and the intoxicated treated rats, reflecting an achievement of learning and spatial memory performance. In conclusion, the extract of Pimpinella anisum L. has a beneficial effect on the nervous system of adult rats poisoned by imidacloprid. [ABSTRACT FROM AUTHOR]