Heterogeneous organocatalysis for the asymmetric desymmetrization of meso-cyclic anhydrides using silica gel-supported bis-cinchona alkaloids

Abstract: The silica gel-supported bis-cinchona alkaloid 1a</ce:inter-ref> was prepared and found to be an efficient heterogeneous chiral organocatalyst with high catalytic activities, enantioselectivities (up to 92% ee), and recyclability for the asymmetric desymmetrization of meso-cyclic anhydrides with alcoholysis. [Copyright &y& Elsevier]