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The homozygosity for 10-repeat allele at dopamine transporter gene and dopamine transporter density in Korean children with attention deficit hyperactivity disorder: relating to treatment response to methylphenidate
- Source :
-
European Neuropsychopharmacology . Jan2005, Vol. 15 Issue 1, p95-101. 7p. - Publication Year :
- 2005
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Abstract
- Abstract: The symptoms of attention deficit hyperactivity disorder (ADHD) can be treated with methylphenidate (MPH), a potent blocker of dopamine transporter (DAT). The homozygosity of the 10-repeat allele at the DAT gene (DAT1) seems to be associated with a poor response to MPH in children with ADHD. In the present study, we investigated the association between DAT density using I-123-N-(3-iodopropen-2-yl)-2β-carbomethoxy-3beta-(4-chlorophenyl)tropane [123I]IPT single photon emission computed tomography (SPECT)] and the homozygosity for 10-repeat allele at DAT1 and response to MPH in Korean children with ADHD. Eleven drug-naive children with ADHD were included in the study and treated with MPH for about 8 weeks. After the genotyping and SPECT were performed, we compared DAT density between ADHD children with and without the homozygosity for 10-repeat allele at DAT1 and investigated the correlation between the homozygosity for 10-repeat allele and response to MPH. ADHD children with 10/10 genotype (n=7) had a significantly greater increase of the DAT density in basal ganglia than the children without 10/10 genotype (n=4). We found that while only 28.6% (2/7) of the subject with 10/10 genotype showed good response to MPH treatment, 100% (4/4) of the subjects without 10/10 genotype showed good response to MPH treatment. Our findings support an association between homozygosity for 10-repeat allele at DAT1 and the DAT density assessed in vivo and correlation between the homozygosity for 10-repeat allele and poor response to MPH. [Copyright &y& Elsevier]
- Subjects :
- *NEUROTRANSMITTERS
*CATECHOLAMINES
*GENETIC polymorphisms
*GENETIC research
Subjects
Details
- Language :
- English
- ISSN :
- 0924977X
- Volume :
- 15
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- European Neuropsychopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 15552660
- Full Text :
- https://doi.org/10.1016/j.euroneuro.2004.06.004