What Do These Findings Tell Us? Comment on Tinella et al. Cognitive Efficiency and Fitness-to-Drive along the Lifespan: The Mediation Effect of Visuospatial Transformations. Brain Sci. 2021, 11 , 1028.

The regression weights or path coefficients that depict the magnitude of associations of arrows in path diagrams are maximized for the study sample, in keeping with the least-squares criterion. Although the MoCA serves well to predict cognitive impairment and to identify persons having Alzheimer's dementia or mild cognitive impairment [[26]], its meaning becomes unclear when applied to a sample of cognitively intact individuals. The MoCA was developed as a measure of cognitive impairment in elderly persons suspected of developing dementia or mild cognitive impairment and was validated on a sample of three groups of elderly adults: Alzheimer's disease, mild cognitive impairment, or no cognitive impairment [[25]]. The earlier study included 120 males and 63 females, ages 18-64, whereas the more recent study included only 117 males, ages 18-64, and added 58 males, ages 65-91. [Extracted from the article]