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A detailed study on multifaceted bioactivities of the extracts and isolated compounds from truffle Reddellomycesparvulosporus.

Authors :
Çayan, Fatih
Tel‐Çayan, Gülsen
Deveci, Ebru
Duru, Mehmet Emin
Türk, Mustafa
Source :
International Journal of Food Science & Technology. Mar2022, Vol. 57 Issue 3, p1411-1419. 9p.
Publication Year :
2022

Abstract

Mushrooms and truffles are attracting attention as a new generation of biotherapeutics. In the current study, isolation, phenolic and organic acid composition, and antioxidant, cytotoxic, anticholinesterase activities of truffle Reddellomyces parvulosporus were examined. Four known compounds (brassicasterol (1), ergosterol peroxide (2), fumaric acid (3) and mannitol (4)) were isolated with the combination of chromatographic techniques. Fumaric acid (54.74 ± 0.85 µg g−1) was found as the major compound by HPLC‐DAD. All isolated compounds were bioassayed for antioxidant, cytotoxic, anticholinesterase, anti‐tyrosinase, anti‐urease, anti‐α‐glucosidase and anti‐α‐amylase activities. Compound 1 indicated notable cytotoxic activity on MCF‐7 (IC50: 38.08 ± 0.75 µg mL−1) and compound 3 on H1299 (IC50: 62.37 ± 0.75 µg mL−1). Also, compounds 1 (84.55 ± 1.14%) and 2 (84.90 ± 0.10%) showed higher anti‐urease activity than thiourea (78.57 ± 0.22%), while compound 2 (66.31 ± 0.08%) displayed near‐standard anti‐BChE activity. Also, being the first to emphasise the potential of R. parvulosporus as a natural food additive, this study evidenced its medicinal importance by revealing bioactive compounds and properties. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
09505423
Volume :
57
Issue :
3
Database :
Academic Search Index
Journal :
International Journal of Food Science & Technology
Publication Type :
Academic Journal
Accession number :
155381626
Full Text :
https://doi.org/10.1111/ijfs.15190