Uso de estatinas é associado à menor mortalidade de causa cardiovascular em pacientes em diálise candidatos ao transplante renal.

Background: Cardiovascular (CV) diseases are major causes of mortality in renal transplant candidates. Objective: To evaluate the association between clinical and laboratorial variables, findings in coronary angiography and use of medicines with CV death in patients undergoing dialysis who were renal transplant candidates. Methods: An observational, longitudinal study was conducted in 103 renal transplant candidates from two transplant centers. The association between CV death and clinical variables was also investigated. Those variables that showed an association with the outcome variable at p<0,1 were selected for Cox analysis. Age and presence of diabetes mellitus were forced in the model. Results: We screened 128 patients, 20 of which were excluded because they refused to participate in the study and three died before the study started. Of the remaining 105 patients, two were excluded due to failures in the outcome records, so 103 were included in the longitudinal analysis. The univariate analysis did not identify the clinical variable that was associated with the occurrence of CV death. However, dialysis modality and statin use were selected for multiple analysis because they were associated with the outcome at p<0,1. Cox analysis to assess the association between clinical variables and the occurrence of CV death in dialysis patients only identified statin use as a predictor of lower risk of CV death (Hazard Ratio -- HR=0,106, 95% confidence interval -- 95%CI 0,013-0,852; p=0,035). Conclusion: In patients on dialysis who were candidates to renal transplantation only statin use showed an inverse, statistically significant association with the occurrence of CV death. [ABSTRACT FROM AUTHOR]