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The mechanism of sugar produced from simple glycolaldehyde derivative at ambient conditions.
- Source :
-
International Journal of Quantum Chemistry . 4/5/2022, Vol. 122 Issue 7, p1-6. 6p. - Publication Year :
- 2022
-
Abstract
- A benchmark of sugar produced from simple glycolaldehyde derivative has been achieved at ambient conditions (Science, 2004, 305, 1752), which is the most important step to produce life in nature. However, the mechanism has never been clearly understood. Here, we report a reaction mechanism which includes a two‐step synthesis of sugars by selective aldol reactions based on the density functional theory (DFT) calculations. Results show that the prochirality of attacking orientation of the enamine intermediate and steric effect in proton transfer is the main cause for stereochemical preference. This work provides the theoretical insight of sugar produced in glycolaldehyde procedure and may assist the improvement of catalyst design for this procedure. [ABSTRACT FROM AUTHOR]
- Subjects :
- *SUGARS
*SUGAR
*DENSITY functional theory
*CATALYSTS
*PROCHIRALITY
Subjects
Details
- Language :
- English
- ISSN :
- 00207608
- Volume :
- 122
- Issue :
- 7
- Database :
- Academic Search Index
- Journal :
- International Journal of Quantum Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 155323349
- Full Text :
- https://doi.org/10.1002/qua.26865