Evaluation of the extraction process parameters on bioactive compounds of cinnamon bark: A comparative study.

[Display omitted] • Cinnamaldehyde and cinnamic acid were extracted from cinnamon bark. • Cinnamaldehyde and cinnamic acid were analyzed by HPLC and UV–vis spectroscopy. • Maximum efficiency of the microwave extraction method was 85 % of the soxhlet. • Maximum efficiency of the ultrasonic extraction method was 65 % of the soxhlet. • Microwave and ultrasonic extractions process parameters were optimized. In recent times, there has been special attention to the antidiabetic properties of herbal medicine like cinnamon, because of its major compounds such as cinnamic acid and cinnamaldehyde. This study optimizes an effective technique for the extraction of cinnamic acid and cinnamaldehyde from cinnamon bark. The effective parameters of both microwave and ultrasound methods were considered and then compared with the soxhlet extraction method. The impact of different solvent types, temperature and process time, solid: solvent portion, particle size, on the yield of cinnamic acid and cinnamaldehyde extraction were investigated. In addition, all the obtained extraction samples were analyzed by the newly developed HPLC method via UV detector. Finally, the optimized extraction factors were obtained 85 % aqueous ethanol; solid: solvent portion, 1:40 g/mL; particle size of 0.18 mm; for both microwave and ultrasound extraction methods. The maximum yield of cinnamic acid and cinnamaldehyde in microwave extraction were gained 3.9 and 49.4 mg/g, respectively. Both advanced extraction techniques with our obtained optimized conditions are suggested for cinnamon bark. [ABSTRACT FROM AUTHOR]