Back to Search
Start Over
Whole-Genome Analysis of a High-Risk Clone of Klebsiella pneumoniae ST147 Carrying Both mcr-1 and blaNDM-1 Genes in Peru.
- Source :
-
Microbial Drug Resistance: Mechanism, Epidemiology, & Disease . Feb2022, Vol. 28 Issue 2, p171-179. 9p. - Publication Year :
- 2022
-
Abstract
- The increasing prevalence and dissemination of carbapenemase-producing Enterobacterales represent a serious concern for public health. We studied the genetic features of a multidrug-resistant isolate of high-risk clone ST147 Klebsiella pneumoniae coharboring mcr-1 and blaNDM-1 recovered from a human clinical urine sample in 2017 in Peru. Whole-genome sequencing and conjugation assays identified mcr-1 and blaNDM-1 genes on two different conjugative plasmids, which belong to IncI2 and IncFIB/HI1B incompatibility groups, respectively. The presence of blaCTX-M-15 (in the studied isolate, located on the chromosome) and mutations in GyrA S83I and ParC S80I were detected, as expected for ST147. In addition, other β-lactamases (blaTEM-26 and blaOXA-1) and PMQR (qnrE2 and aac(6′)-Ib-cr) among several resistance determinants were identified. The coexistence not previously described of these genes in the same high-risk clone is a cause for serious concern that supports the need for implementation of genomic surveillance studies. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10766294
- Volume :
- 28
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Microbial Drug Resistance: Mechanism, Epidemiology, & Disease
- Publication Type :
- Academic Journal
- Accession number :
- 155255787
- Full Text :
- https://doi.org/10.1089/mdr.2021.0128