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Visible‐light‐promoted Radical Cyclization/Arylation Cascade for the Construction of α,α‐Difluoro‐γ‐Lactam‐Fused Quinoxalin‐2(1H)‐Ones.
- Source :
-
Chinese Journal of Chemistry . Mar2022, Vol. 40 Issue 6, p713-718. 6p. - Publication Year :
- 2022
-
Abstract
- Comprehensive Summary: A visible‐light‐induced tandem radical intramolecular cyclization/arylation of quinoxalin‐2(1H)‐ones with bromodifluoroacetamides is described. This protocol allows efficient access to a variety of valuable α,α‐difluoro‐γ‐lactam‐fused quinoxalin‐2(1H)‐ones in moderate to good yields under metal‐free, mild and redox neutral reaction conditions. This strategy is tolerant of various functional groups and a broad range of substrates. The mechanism experiments suggested an involvement of 5‐exo‐trig cyclization and a radical process in this transformation. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 1001604X
- Volume :
- 40
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Chinese Journal of Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 155254226
- Full Text :
- https://doi.org/10.1002/cjoc.202100787