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Low serum osteocalcin levels are associated with diabetes mellitus in glucocorticoid treated patients.
- Source :
-
Osteoporosis International . Mar2022, Vol. 33 Issue 3, p745-750. 6p. 2 Charts. - Publication Year :
- 2022
-
Abstract
- Summary: Bone turnover markers are decreased in GC-treated subjects with DM. Decreased OC levels in GC-treated patients were associated with an increased risk of DM. These results suggest the involvement of OC in glucose homeostasis regulation in DM. Introduction: Osteocalcin (OC) is involved in the regulation of glucose homeostasis. Glucocorticoid (GC) treatment is associated with impaired osteoblast function, decreased OC levels, and the development and/or worsening of pre-existing diabetes mellitus (DM). Whether decreased OC levels in GC-treated subjects contribute to DM is not well known. The aim of this study was to analyse whether OC levels in GC-treated patients are associated with the presence of DM. Methods: One hundred twenty-seven patients (aged 61.5 ± 17.9 years) on GC treatment were included. GC dose, treatment duration, presence of DM and bone formation (OC, bone ALP, PINP) and resorption markers (urinary NTX, serum CTX) were analysed. The cut-offs of each bone turnover marker (BTM) for the presence of DM were evaluated and optimised with the Youden index and included in the logistic regression analysis. Results: Among the patients, 17.3% presented DM. No differences were observed in GC dose or duration or the presence of fractures. Diabetics showed lower levels of OC (7.57 ± 1.01 vs. 11.56 ± 1; p < 0.001), PINP (21.48 ± 1.01 vs. 28.39 ± 1; p = 0.0048), NTX (24.91 ± 1.01 vs. 31.7 ± 1; p = 0.036) and CTX (0.2 ± 1.01 vs. 0.3 ± 1; p = 0.0016). The discriminating BTM cut-offs for DM presence were < 9.25 ng/mL for OC, < 24 ng/mL for PINP, < 27.5 nMol/mM for NTX and < 0.25 ng/mL for CTX. In a multivariate logistic regression model adjusted for GC dose, BMI, age and the above four BTMs, only OC remained independently associated with DM presence. Thus, in a model adjusted for GC dose, BMI and age, OC was significantly associated with DM (OR: 6.1; 95%CI 1.87–19.89; p = 0.001). Conclusion: Decreased OC levels in GC-treated patients are associated with increased odds of DM, and only OC was independently associated with DM in a model including four BTMs. [ABSTRACT FROM AUTHOR]
- Subjects :
- *DIABETES risk factors
*GLUCOCORTICOIDS
*BIOMARKERS
*STATISTICS
*COLLAGEN
*BONE growth
*CONFIDENCE intervals
*INFLAMMATION
*OSTEOCALCIN
*BONE resorption
*MULTIPLE regression analysis
*TREATMENT duration
*DIABETES
*RISK assessment
*DESCRIPTIVE statistics
*BONE remodeling
*DATA analysis
*ODDS ratio
*PEPTIDES
Subjects
Details
- Language :
- English
- ISSN :
- 0937941X
- Volume :
- 33
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Osteoporosis International
- Publication Type :
- Academic Journal
- Accession number :
- 155238784
- Full Text :
- https://doi.org/10.1007/s00198-021-06167-z