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Enlarged cavum septi pellucidi Z-scores in fetuses with trisomy 18.
- Source :
-
Journal of Maternal-Fetal & Neonatal Medicine . Mar 2022, Vol. 35 Issue 5, p981-986. 6p. - Publication Year :
- 2022
-
Abstract
- We aim to establish a formula calculating the fetal cavum septi pellucidi (CSP) width Z-scores and compare CSP width between the normal fetus and 18-trisomy fetus. In this retrospective study, 608 normal fetuses and 71 fetuses with the 18-trisomy syndrome were included. Z-scores were calculated after the acquisition of CSP images. Normal CSP width Z-scores formulae were constructed based on gestational age (GA) by performing a standard regression analysis followed by weighted regression of absolute residual values. Subsequently, the Mann–Whitney U test was used to compare the CSP width Z-scores between normal and 18-trisomy groups. Formulae calculating CSP width Z-scores were constructed. Normal fetal CSP width was significantly correlated with GA (R2 = 0.50, p <.01). In 18-trisomy group, 69% (34/49) fetuses displayed enlarged fetal CSP width and CSP width Z-scores (p <.01). The CSP width Z-scores formulae established in the current study can provide a quantitative basis for the prenatal diagnosis of 18-trisomy syndrome. Enlarged CSP width Z-score may serve as a novel prenatal diagnostic marker for the 18-trisomy syndrome. [ABSTRACT FROM AUTHOR]
- Subjects :
- *TRISOMY 18 syndrome
*MANN Whitney U Test
*FETUS
*GESTATIONAL age
*ABSOLUTE value
Subjects
Details
- Language :
- English
- ISSN :
- 14767058
- Volume :
- 35
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Journal of Maternal-Fetal & Neonatal Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 155145102
- Full Text :
- https://doi.org/10.1080/14767058.2020.1742321