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The prognosis of HPV-associated metastatic pharyngeal patients by primary and distant site.
- Source :
-
Oral Oncology . Feb2022, Vol. 125, pN.PAG-N.PAG. 1p. - Publication Year :
- 2022
-
Abstract
- <bold>Objectives: </bold>Human papillomavirus (HPV) positivity is a favorable prognostic factor in the general population of head and neck squamous cell carcinoma (HNSCC) patients. However, its impact on the survival of metastatic HNSCC of pharynx (mHNSC-P) patients is unclear. This study aims to investigate the associations between HPV status and survival in mHNSC-P patients.<bold>Methods: </bold>735 mHNSC-P patients diagnosed at first presentation from 2010 to 2016 were retrieved from the Surveillance, Epidemiology and End Result database (SEER). Chi-Squared test, univariate and multivariate cox proportional hazards model, Kaplan-Meier analysis, and log-rank test were applied to compare HPV-positive and -negative mHNSC-P patients.<bold>Result: </bold>Using univariate cox proportional hazards analysis, HPV status, primary site, T stage, treatment and distant metastatic site correlate with the overall survival (OS) and disease-specific survival (DSS) in mHNSC-P patients. Multivariate cox regression analysis shows that HPV-positive mHNSC-P patients experienced significantly better OS (HR: 0.62 CI: 0.51-0.76, p < 0.001) and DSS (HR: 0.73 CI: 0.58-0.91, p < 0.01) as compared to HPV-negative mHNSC-P patients. Subgroup analysis indicates that HPV-associated OS and DSS benefits exist in patients with metastatic HNSCC of oropharynx (mHNSC-OP) but not in patients with metastatic HNSCC of non-oropharynx (mHNSC-non-OP). Among mHNSC-OP patients, HPV positivity confers disease-specific survival benefit in patients with oligometastatic rather than polymetastatic patients. Furthermore, HPV associated OS and DSS advantages in mHNSC-OP with lung metastasis was observed.<bold>Conclusion: </bold>HPV-positive mHNSC-OP patients with lung metastasis show better survival than HPV-negative mHNSC-OP patients, providing key information to guide patient treatment approaches. [ABSTRACT FROM AUTHOR]
- Subjects :
- *PROPORTIONAL hazards models
*PAPILLOMAVIRUSES
*SQUAMOUS cell carcinoma
*CERVICAL intraepithelial neoplasia
*PHARYNX
*ARTHRITIS Impact Measurement Scales
*OROPHARYNGEAL cancer
*LUNG tumors
*HEAD & neck cancer
*RETROSPECTIVE studies
*PROGNOSIS
*PAPILLOMAVIRUS diseases
*IMPACT of Event Scale
*QUESTIONNAIRES
*DISEASE complications
Subjects
Details
- Language :
- English
- ISSN :
- 13688375
- Volume :
- 125
- Database :
- Academic Search Index
- Journal :
- Oral Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 155091436
- Full Text :
- https://doi.org/10.1016/j.oraloncology.2021.105675