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Combined Photoredox and Carbene Catalysis for the Synthesis of γ‐Aryloxy Ketones.
- Source :
-
Advanced Synthesis & Catalysis . 2/1/2022, Vol. 364 Issue 3, p518-524. 7p. - Publication Year :
- 2022
-
Abstract
- N‐heterocyclic carbenes (NHCs) have emerged as catalysts for the construction of C−C bonds in the synthesis of substituted ketones under single‐electron processes. Despite these recent reports, there still remains a need to increase the utility and practicality of these reactions by exploring new radical coupling partners. Herein, we report the synthesis of γ‐aryloxyketones via combined NHC/photoredox catalysis. In this reaction, an α‐aryloxymethyl radical is generated via oxidation of an aryloxymethyl potassium trifluoroborate salt, which is then added into styrene derivatives to provide a stabilized benzylic radical. Subsequent radical‐radical coupling reaction with an azolium radical affords the γ‐aryloxy ketone products. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CARBENE synthesis
*KETONES
*STYRENE derivatives
*POTASSIUM salts
*CARBENES
Subjects
Details
- Language :
- English
- ISSN :
- 16154150
- Volume :
- 364
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Advanced Synthesis & Catalysis
- Publication Type :
- Academic Journal
- Accession number :
- 155006175
- Full Text :
- https://doi.org/10.1002/adsc.202101354