Uterine nerve fibre proliferation in advanced endometriosis.

The article discusses a case that offers an explanation as Laparoscopy demonstrated advanced endometriosis with involvement of both uterosacral ligaments and ovaries, obliteration of the pouch of Douglas, dense adhesions of both ovaries and fallopian tubes to peritoneal surfaces and extensive neovascularisation of the uterus and peritoneal surfaces. Immunohistochemistry with S-100, a monoclonal antibody used to demonstrate nerves, showed widespread nerve fibre proliferation in the uterus, cervix and uterosacral ligaments. The striking observation was of extensive perivascular nerve fibre proliferation around both arteries and veins that was prominent throughout the uterine isthmus.