Introduction to a series of Pro/Con papers in Clinical Toxicology.

The Cochrane Library published a systematic review of interventions for paracetamol overdose in 2018.8 The conclusion begins: 'These results highlight the paucity of randomised clinical trials comparing different interventions for paracetamol overdose and their routes of administration and the low or very low level quality of the evidence that is available'. Disproportionate effect on child admissions of the change in Medicines and Healthcare Products Regulatory Agency guidance for management of paracetamol poisoning: an analysis of hospital admissions for paracetamol overdose in England and Scotland. Keywords: poisoning; research; toxicology EN poisoning research toxicology 56 57 2 02/01/22 20220101 NES 220101 Clinical Toxicology is one of the core sub-specialities of Clinical Pharmacology and Therapeutics. [Extracted from the article]