Tissue eosinophils express the IL‐33 receptor ST2 and type 2 cytokines in patients with eosinophilic esophagitis.

Tissue eosinophils express the IL-33 receptor ST2 and type 2 cytokines in patients with eosinophilic esophagitis Keywords: clinical immunology; eosinophils; flow cytometry; interleukins; mucosal immunity EN clinical immunology eosinophils flow cytometry interleukins mucosal immunity 656 660 5 02/01/22 20220201 NES 220201 ACKNOWLEDGMENTS We would like to acknowledge the contributions from the Harvard Stem Cell Institute-Center for Regenerative Medicine Flow Cytometry Core and the Program for Membrane Biology Microscopy Core at Simches Research Center, Massachusetts General Hospital. ST2 was robustly detected on tissue eosinophils from patients with active EoE (Figure 1C, 1E), whereas blood eosinophils from healthy control, remission, and active EoE were uniformly low for ST2 (Figure 1D, 1F-G; Figure S1). [Extracted from the article]