Preparation of hollow mesoporous prussian blue coated with mesoporous silica shell nanocubes for photothermal therapy and drug carrier.

The nanocubes with Hollow Prussian blue core and mesoporous silica shell were prepared for the first time. The prepared nanocubes combined photothermal therapy and drug controlled release properties with higher drug loading capacity, while the surface silica shell would provide the conditions for further compositing of other functional materials. [Display omitted] • The mesoporous silica coated PB-based nanocubes with hollow core were prepared for first time. • The prepared nanocubes exhibit higher drug loading capacity. • The nanocubes combine the functions of photothermotherapy and drug delivery. The nanocubes with hollow mesoporous Prussian blue core and mesoporous silica shell (HMPB@mSiO 2) were prepared. According to the SEM and TEM, the material showed a regular hollow core-shell cubic structure. Up to 879 m2/g of the surface area and 4.2 nm of average pore size were measured by N 2 adsorption-desorption. The nanocubes exhibited excellent photothermal conversion efficiency under 808 nm NIR. The UV–vis spectrophotometry showed that the drug loading content of the materials were 868.27 μg/mg (drug/carrier) and which can accelerate the release of DOX under acidic and NIR conditions. [ABSTRACT FROM AUTHOR]