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Impact of chitosan-based nanocarriers on cytoskeleton dynamics: Current status and challenges.
- Source :
-
Biocell . 2022, Vol. 46 Issue 3, p885-891. 7p. - Publication Year :
- 2022
-
Abstract
- Chitosan-based nanocarriers (CS-NCs) show a promising role in improving drugs and bioactive compounds delivery for therapy. However, the effects exerted by CS-NCs at the cellular level, including their recognition and uptake, have not been fully investigated yet. Many factors, including size, shape, concentration, and surface chemistry of CS-NCs, play an important role in determining the types of intracellular signals triggered. The mechanism of uptake and the involvement of the cytoskeleton during the CS-NCs endocytosis variates among the different cell types as well as further effects observed inside cells. In the present work, we discuss the effects induced by CS-NCs per se on the cytoskeleton, a key component in cell architecture and physiology. The focus of this report is made on tumoral and normal biological models in which CS-NCs could differentially affect the cell cytoskeleton. The recent years reports regarding the impact of CS-NCs on cytoskeleton dynamics and the current techniques for its evaluation are summarized and discussed. Understanding mechanisms underlying cytoskeletal impact after cell exposure to CS-NCs is critical for the design of safest value-added formulations in the biomedical field. Furthermore, this revision points out some interesting aspects of cytoskeletal changes and cell death encompassing anti-tumoral effects. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CHITOSAN
*BIOACTIVE compounds
*SURFACE chemistry
*ENDOCYTOSIS
*CELL death
Subjects
Details
- Language :
- English
- ISSN :
- 03279545
- Volume :
- 46
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Biocell
- Publication Type :
- Academic Journal
- Accession number :
- 154703808
- Full Text :
- https://doi.org/10.32604/biocell.2022.018391