HISTOLOGICAL PATTERN OF NON-DIABETIC RENAL DISEASE IN TYPE 2 DIABETES MELLITUS. A STUDY IN A TERTIARY CARE HOSPITAL.

OBJECTIVE: To determine the histological pattern of non-diabetic renal disease in type 2 diabetes mellitus. MATERIAL AND METHODS: This descriptive, cross-sectional study was conducted in the Nephrology department MTI Lady Reading Hospital Peshawar from January 2018 to January 2021. All type 2 diabetic patients with normal fundi were included in the study irrespective of time duration. A total of 30 patients were registered. Their biodata was entered in a prescribed proforma. Those having normal fundi were included in the study and were then exposed to renal biopsy. Those patients having diabetic retinal changes were excluded from the study. RESULTS: Out of 30 patients, males were 20 and females were 10 with a ratio of 2:1 with a mean age of 55.5±13.3SD years. Pure diabetic nephropathy (DN) was noted in 9 (30%) cases, Non-Diabetic Renal Disease (NDRD) in 13 (43.3%) cases, and NDRD on DN in 8 (26.7%) cases. Among the Non-Diabetic Renal Disease (NDRD), Membranous Glomerulonephritis (MGN) was present in 9 (30%) cases, Acute Tubular Necrosis (ATN) in 5 (16.6%) cases, Focal Segmental Glomerulosclerosis (FSGN) in 4 (13.33%.) cases, Mesangiocapillary Glomerulonephritis (MCGN) in 2 (6.7%) cases and Hemolytic Uremic Syndrome (HUS) in 1 (3.3%) cases. CONCLUSION: It was concluded from the study that the absence of diabetic retinopathy does not exclude diabetic nephropathy. Renal biopsy should be done in all patients with type 2 DM irrespective of time duration especially with normal fundi and atypical renal involvement. [ABSTRACT FROM AUTHOR]