Neoadjuvant intralesional methotrexate for juvenile xanthogranuloma in an adult.

Juvenile xanthogranuloma (JXG) is a non-Langerhans cell histiocytosis usually occurring in infants and typically located in the head or neck.1 Clinically, solitary skin lesions are found in 60%-82% of patients and the most common variant is characterized by one yellowish nodule. Further studies are needed to help determine the efficacy and safety of this treatment in non-spontaneously resolved JXG and in other non-Langerhans cell histiocytoses limited to the skin, in which it could also be an alternative. In this respect, it is worthy of mention that characteristic histopathological clues of JXG as presence of xanthomatous/foamy histiocytes or Touton cells were not observed in any case.10 As noted above, spontaneous resolution of adult onset JXG is uncommon, and an area of atrophy frequently develops. [Extracted from the article]