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DermaVir: A Novel Topical Vaccine for HIV/AIDS.
- Source :
-
Journal of Investigative Dermatology . Jan2005, Vol. 124 Issue 1, p160-169. 10p. - Publication Year :
- 2005
-
Abstract
- Human immunodeficiency virus (HIV) vaccines have the potential to improve antiretroviral drug treatment by inducing cytotoxic killing of HIV-infected cells. Prophylactic vaccines utilize new antigens to initiate immunity; however, in HIV-infected individuals the load of viral antigen is not the limiting factor for the restoration of immune responses. Here we describe a novel immunization strategy with DermaVir that improves viral antigen presentation using dendritic cells (DC). DermaVir contains a distinctive plasmid DNA expressing all HIV proteins except integrase to induce immune responses with broad specificity. The DNA is formulated to a mannosilated particle to target antigen-presenting cells and to protect the DNA from intracellular degradation. After topical application, DermaVir-transduced cells migrate from the skin to the draining lymph node and interdigitate as DermaVir-expressing, antigen-presenting DC. We compared the immunogenicity of topical andex vivoDC-based DermaVir vaccinations in naïve rhesus macaques. Both vaccinations induced simian immunodeficiency virus-specific CD4 helper and CD8 memory T cells detected by anin vivoskin test and anin vitrointracellular cytokine-based assay. Topical DermaVir vaccination represents an improvement upon existingex vivoDC-based immunization technologies and may provide a new therapeutic option for HIV-infected patients. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ANTIRETROVIRAL agents
*HIV
*AIDS
*HIV-positive persons
*DENDRITIC cells
*DNA
Subjects
Details
- Language :
- English
- ISSN :
- 0022202X
- Volume :
- 124
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Journal of Investigative Dermatology
- Publication Type :
- Academic Journal
- Accession number :
- 15456826
- Full Text :
- https://doi.org/10.1111/j.0022-202X.2004.23535.x