Back to Search Start Over

Changing places: Chromosomal Passenger Complex relocation in early anaphase.

Authors :
Hadders, Michael A.
Lens, Susanne M.A.
Source :
Trends in Cell Biology. Feb2022, Vol. 32 Issue 2, p165-176. 12p.
Publication Year :
2022

Abstract

The Chromosomal Passenger Complex (CPC) regulates a plethora of processes during multiple stages of nuclear and cytoplasmic division. Early during mitosis, the CPC is recruited to centromeres and kinetochores, and ensures that the duplicated chromosomes become properly connected to microtubules from opposite poles of the mitotic spindle. Progression into anaphase is accompanied by a striking relocation of the CPC from centromeres to the antiparallel microtubule overlaps of the anaphase spindle and to the equatorial cortex. This translocation requires direct interactions of the CPC with the kinesin-6 family member MKLP2/KIF20A, and the inactivation of cyclin B-cyclin-dependent kinase-1 (CDK1). Here, we review recent progress in the regulation of this relocation event. Furthermore, we discuss why the CPC must be relocated during early anaphase in light of recent advances in the functions of the CPC post metaphase. A key feature of the CPC is that it changes location during early anaphase, from the centromeric region of the chromosomes to the anaphase spindle midzone and the equatorial cell cortex. Relocation requires the inactivation of cyclin B-CDK1 and the subsequent dephosphorylation of INCENP and MKLP2/KIF20A, to promote CPC-MKLP2 complex formation and to stimulate ATPase activity of MKLP2. At the spindle midzone and equatorial cortex, the CPC promotes anaphase spindle remodeling and the initiation of cytokinesis. Spindle midzone-localized CPC is proposed to support the timely resolution of lagging chromosomes during anaphase. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
09628924
Volume :
32
Issue :
2
Database :
Academic Search Index
Journal :
Trends in Cell Biology
Publication Type :
Academic Journal
Accession number :
154506553
Full Text :
https://doi.org/10.1016/j.tcb.2021.09.008