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Antinuclear antibodies in patients with endometriosis: A cross-sectional study in 94 patients.
- Source :
-
Human Immunology . Jan2022, Vol. 83 Issue 1, p70-73. 4p. - Publication Year :
- 2022
-
Abstract
- Markers of autoimmunity, such as autoantibodies, have been found in patients with endometriosis. These include the antinuclear antibodies (ANA). We aimed to evaluate the prevalence of ANA in a sample of patients with endometriosis and its possible clinical associations. Ninety-four patients with endometriosis and 91 controls were studied for ANA and extractable nuclear antigen (ENA; anti-Ro, anti-La, anti-Sm, and anti-RNP) profiles and anti-dsDNA. Epidemiological, clinical, and staging data in endometriosis were obtained. Patients with autoimmune disorders were excluded. Patients with endometriosis had a 21.2% prevalence of positive ANA vs. 5.4% in controls (P = 0.001). The ENA profile and anti-dsDNA were negative. Patients with positive ANA were more asymptomatic (P = 0.03) and had less dysmenorrhea. No associations with disease duration, patient age, or endometriosis stage were found. We found a high prevalence of positive ANA in patients with endometriosis. The presence of this autoantibody may be linked to a milder clinical expression of the disease. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 01988859
- Volume :
- 83
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Human Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 154505329
- Full Text :
- https://doi.org/10.1016/j.humimm.2021.10.001