二甲胺四环素联合茶多酚对早期种植体周围软组织炎患者牙周指标、 炎性因子以及龈沟液 RANKL Shh 水平的影响.

To investigate the effect of minocycline combined with tea polyphenols on periodontal index, inflammatory factors, gingival crevicular fluid nuclear factor kappa β receptor activator ligand (RANKL), Hedgehog factor (Shh) levels in patients with early peri implant soft tissue inflammation. A total of 106 patients with early peri-implant soft tissue inflammation admitted to our hospital were included in this study, they were divided into control group (n=53, treated with minocycline) and study group (n=53, treated with tea polyphenol on the basis of minocycline) by envelope lottery. The periodontal index, curative effect, inflammatory factors, RANKL and Shh levels in gingival crevicular fluid of the two groups before treatment and after 4 weeks of treatment were compared, adverse reactions of the two groups during treatment were recorded. The total clinical effective rate of the study group at 4 weeks after treatment was higher than that of the control group (P<0.05). The modified plaque index (mPLI), modified gingival sulcus bleeding index (mSBI), periimplant pocket depth (PPD), serum interleukin-1β(IL-1β), monocyte chemoattractant protein-1 (MCP-1), RANKL and Shh levels in gingival sulcus fluid decreased in the two groups at 4 weeks after treatment, and study group was lower than the control group (P<0.05). There was no significant difference between incidence of adverse reactions of the two groups (P>0.05). Minocycline combined with tea polyphenols in the treatment of patients with early periimplant soft tissue inflammation are significant efficacy, which can effectively improve the periodontal situation of patients, reduce the serum IL-1β, MCP-1levels and RANKL, Shh levels in gingival crevicular fluid, which is safe and reliable. [ABSTRACT FROM AUTHOR]