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The immunosenescence-related factor DOCK11 is involved in secondary immune responses of B cells.
- Source :
-
Immunity & Ageing . 1/3/2022, Vol. 19 Issue 1, p1-10. 10p. - Publication Year :
- 2022
-
Abstract
- Background: Memory B cells are an antigen-experienced B-cell population with the ability to rapidly differentiate into antibody-producing cells by recall responses. We recently found that dedicator of cytokinesis 11 (DOCK11) contributes to the expansion of antigen-specific populations among germinal center B cells upon immunization. In comparison, limited information is available on the contribution of DOCK11 to secondary humoral immune responses. Results: In this study, effects of the DOCK11 deficiency in B cells were examined on secondary immune responses to protein antigen. The lack of DOCK11 in B cells resulted in the impaired induction of antibody-producing cells upon secondary immunization with protein antigen. DOCK11 was dispensable for the recall responses of antigen-experienced B cells, as demonstrated by the comparable induction of antibody-producing cells in mice given transfer of antigen-experienced B cells with no DOCK11 expression. Instead, the lack of DOCK11 in B cells resulted in the impaired secondary immune responses in a B cell-extrinsic manner, which was recovered by the adoptive transfer of cognate T cells. Conclusions: We addressed that intrinsic and extrinsic effects of DOCK11 expression in B cells may contribute to secondary humoral immune responses in manner of the induction of cognate T-cell help. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 17424933
- Volume :
- 19
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Immunity & Ageing
- Publication Type :
- Academic Journal
- Accession number :
- 154456551
- Full Text :
- https://doi.org/10.1186/s12979-021-00259-4