血清 PRDX1、FGF4、Hepc25 水平与急性缺血性脑卒中患者病情及预后的关系研究.

Objective: To investigate the relationship between serum peroxiredoxin 1 (PRDX1), fibroblast growth factor 4 (FGF4), and hepcidin25 (Hepc25) and the severity of illness and prognosis of patients with acute ischemic stroke (AIS). Methods: 73 patients with AIS (AIS group) who were admitted to our hospital from January 2018 to January 2020 and 56 healthy patients (control group) who underwent physical examination in our hospital during the same period were selected. According to the national institutes of health stroke scale (NIHSS) scores, AIS group were divided into mild group (NIHSS score < 6 scores, 21 cases), moderate group (6 scores ≤ NIHSS score＜13 scores, 38 cases) and severe group (NIHSS score ≥ 13 scores, 14 cases). According to the modified Rankin scale (mRS), the patients was divided into good prognosis group (0 ~ 2 scores, 55 cases) and poor prognosis group (≥ 3 scores, 18 cases). Serum PRDX1, FGF4 and Hepc25 levels in all subjects were detected, the correlation between PRDX1, FGF4, Hepc25 and NIHSS and mRS scores were analyzed, the clinical data of patients with different prognosis were compared, the prognostic factors of AIS patients were analyzed. Results: The serum PRDX1, FGF4, Hepc25 levels in AIS group were higher than those in control group (P<0.05), serum PRDX1, FGF4, Hepc25 levels in severe group were higher than those in moderate group and mild group (P<0.05), the serum PRDX1, FGF4, Hepc25 levels in moderate group were higher than those in the mild group (P<0.05), and serum PRDX1, FGF4, Hepc25 levels in poor prognosis group were higher than those in good prognosis group (P<0.05). Serum PRDX1, FGF4 and Hepc25 levels of patients with AIS were positively correlated with NHISS score and mRS score (r=0.636, 0.794, 0.682; 0.619, 0.705, 0.713, P<0.05). Univariate analysis showed that age, hypertension, diabetes, NIHSS score on admission were related to prognosis (P<0.05). Regression analysis showed that high NIHSS score at admission, high serum PRDX1, FGF4 and Hepc25 levels were risk factors for poor prognosis of patients with AIS (P<0.05). Conclusion: The serum RDX1, FGF4 and Hepc25 levels in patients with AIS are significantly increased. High level of RDX1, FGF4 and Hepc25 are closely related to severe nerve defects and poor prognosis in patients with AIS, and which can be used as biological indicators for the prognosis assessment of AIS. [ABSTRACT FROM AUTHOR]