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Protective role of naringin loaded solid nanoparticles against aflatoxin B1 induced hepatocellular carcinoma.
- Source :
-
Chemico-Biological Interactions . Jan2022, Vol. 351, pN.PAG-N.PAG. 1p. - Publication Year :
- 2022
-
Abstract
- This study examines the hepatoprotective activity of naringin loaded solid nanoparticles (NRG-SLNs) and compared with free naringin (FNRG) against aflatoxin B1 (AFB1) induced hepatocellular carcinoma. The liver's self-healing ability was studied using a self-recovery group that received no therapy. Following AFB1 therapy, rats were given NRG-SLNs produced using the ion-gelation technique. Histology, serum injury indicators, oxidative stress biomarkers, a pro-inflammatory response biomarker, and tumor indicators were used to evaluate the liver tumor and its responsiveness to therapy. At a dosage of 6.18 mg/kg BW, NRG-SLNs (128 ± 4 nm) provided substantially greater hepatoprotection than free NRG. The actions of NRG-SLNs were equivalent to those of silymarin (SILY), which was given at a dosage of 20 mg/kg BW. The lack of regeneration potential of liver tissue after the damage was verified by the self-recovery group. NRG's efficiency in treating hepatic cancer was increased by using SLN's approach. The increased impact is most likely due to: a) enhanced oral bioavailability, b) the regulated and sustained action of enclosed NRG, and c) a decrease in discomfort and toxicity if any after orally administered. NRG-SLNs may be considered as a therapeutic option for hepatic ailments as effectiveness post-induction of liver carcinoma, is demonstrated presently. • Aflatoxins are very poisonous secondary metabolites generated by several fungus species. • NRG has anti-oxidant and anti-inflammatory properties both in vitro and in vivo. • NRG packed into solid lipid nanoparticles for increasing a bioavailability. • NRG-SLNs produced using the ion-gelation technique. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00092797
- Volume :
- 351
- Database :
- Academic Search Index
- Journal :
- Chemico-Biological Interactions
- Publication Type :
- Academic Journal
- Accession number :
- 154241324
- Full Text :
- https://doi.org/10.1016/j.cbi.2021.109711