Back to Search
Start Over
Iron-catalyzed hydroaminocarbonylation of alkynes to produce succinimides with NH4HCO3.
- Source :
-
Journal of Catalysis . Dec2021, Vol. 404, p224-230. 7p. - Publication Year :
- 2021
-
Abstract
- [Display omitted] • The first efficient ligand free iron-catalyzed hydroaminocarbonylation of alkynes to produce succinimides with NH 4 HCO 3 as the ammonia source. • With NH 4 HCO 3 as easy-to-handle ammonia source, a variety of internal and terminal alkynes were well tolerated in this catalytic system. • Preliminary mechanistic studies reveal the activation model involving interactions of NH 4 HCO 3 with both iron catalyst and alkyne substrates. Succinimide derivatives are valuable compounds in synthesis of natural products and pharmaceuticals. A catalytic hydroaminocarbonylation reaction was developed for the synthesis of succinimides from alkynes, CO and NH 4 HCO 3. The novel transformation proceeds in the presence of Fe 3 (CO) 12 without the need for expensive ligands or additives. Various substituted alkynes are selectively transformed into corresponding succinimides in good yields. Preliminary mechanistic studies suggest that NH 4 HCO 3 plays an important role in the formation and stabilization of iron catalyst. [ABSTRACT FROM AUTHOR]
- Subjects :
- *SUCCINIMIDES
*ALKYNES
*IRON catalysts
*NATURAL products
Subjects
Details
- Language :
- English
- ISSN :
- 00219517
- Volume :
- 404
- Database :
- Academic Search Index
- Journal :
- Journal of Catalysis
- Publication Type :
- Academic Journal
- Accession number :
- 154145663
- Full Text :
- https://doi.org/10.1016/j.jcat.2021.09.035