Hit by a Smooth CD8: T-Cell Attack on Hippocampal Neurons Triggers Limbic Encephalitis and Epilepsy.

However, the potential of distinct lymphocyte subsets alone to elicit key clinicopathological sequelae of LE potentially inducing temporal lobe epilepsy (TLE) with chronic spontaneous seizures and hippocampal sclerosis (HS) is unresolved. Commentary Temporal lobe epilepsy (TLE) is a common type of epilepsy characterized by focal seizures that can be drug-resistant.[1] In TLE, the hippocampal and amygdala brain regions are typically damaged and, as a result, cognitive deficits often develop along with recurrent unprovoked seizures.[1],[2] Severe neuronal loss, gliosis, and inflammation in the hippocampus are some of the neuropathological hallmarks of TLE. [Extracted from the article]