阿尔茨海默病患者血清 P-tau-181, 8-OHdG, Lp-PLA2 水平与认知功能的关系及其预测价值分析.

Objective: To investigate the relationship between serum phosphorylated tau-181 (P-tau-181), 8-hydroxydeoxyguanosine (8-OHdG), lipoprotein associated phospholipase A2 (Lp-PLA2) and cognitive function in patients with Alzheimer's disease (AD) and its predictive value analysis. Methods: 90 patients with AD who were admitted in our hospital from January 2018 to December 2019 were selected as AD group, 90 cases of vascular dementia VD patients as VD group, 90 healthy people who had physical examination in our hospital at the same time as the control group, the levels of serum P-tau-181, 8-OHdG, Lp-PLA2, Montreal Cognitive Assessment Scale(MoCA), Mini-mental State Examination(MMSE) and clinical dementia rating scale(CDR) were compared in each group, the serum levels of P-tau-181, 8-OHdG and Lp-PLA2 in AD patients with different degrees of cognitive impairment were compared, and the correlation of each index was analyzed, ROC curve was used to analyze the predictive value of serum P-tau-181, 8-OHdG and Lp-PLA2 levels for AD. Results: The serum levels of P-tau-181, 8-OHdG, Lp-PLA2 in AD group were significantly higher than those of VD group and control group (P<0.05), there was no statistical difference between VD group and control group in serum levels of P-tau-181, 8-OHdG, Lp-PLA2 (P>0.05). The scores of MOCA, MMSE in AD group and VD group were significantly lower than those of control group, CDR score was significantly higher than that of control group(P<0.05), there was no statistical difference in Moca, MMSE and CDR scores between AD group and VD group(P>0.05). With the decrease of cognitive function in AD patients, the serum levels of P-tau-181, 8-OHdG, Lp-PLA2 gradually increased (P<0.05). Pearson correlation analysis showed that serum P-tau-181, 8-OHdG, Lp-PLA2 were negatively correlated with MOCA, MMSE scores, and positively correlated with CDR scores(P<0.05). ROC curve analysis showed that the sensitivity of P-tau-181, 8-OHdG, Lp-PLA2 in the diagnosis of AD was 88.55%, 89.34%, 89.77%, and the specificity was 81.94%, 82.56%, 85.67%. Conclusion: The serum levels of P-tau-181, 8-OHdG, Lp-PLA2 in patients with AD are abnormally elevated, which can reflect the degree of cognitive dysfunction of patients, and have certain value for early diagnosis and differential diagnosis of AD. [ABSTRACT FROM AUTHOR]