首荟通便胶囊联合乳果糖口服液对老年功能性便秘患者焦虑抑郁和血清胃肠激素的影响.

Objective: To investigate the Shouhui Tongbian capsule combined with lactulose oral liquid in the treatment of senile functional constipation’s curative effect and its effect on anxiety, depression and serum gastrointestinal hormones in patients. Methods:150 patients with senile functional constipation who came to our hospital from December 2017 to December 2019 were selected, and randomly divided into group A(n=75, lactulose oral liquid treatment) and group B (n=75, Shouhui Tongbian capsule combined with lactulose oral liquid) according to random number table method. The curative effect of the two groups at 2 weeks after treatment and the occurrence of adverse reactions during treatment were recorded. Serum motilin(MTL), substance P(SP), Zung self rating anxiety scale(SAS) score, Zung self rating depression scale(SDS) and clinical symptom score of patients before treatment and 2 weeks after treatment were compared. Results: 2 weeks after treatment, the scores of stool characteristics, defecation difficulty, defecation incomplete feeling and defecation interval of the two groups decreased, and the group B was lower than group A (P<0.05). The total effective rate of group B at 2 weeks after treatment was 85.33%(64/75), and the total effective rate of group A at 2 weeks after treatment was 69.33%(52/75), the total effective rate of group B was higher than that of group A (P<0.05). 2 weeks after treatment, SAS and SDS scores of two groups decreased, and group B was lower than group A (P<0.05). 2 weeks after treatment, Serum MTL and SP of two groups were increased, and group B was higher than group A (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: Shouhui Tongbian capsule combined with lactulose oral liquid in the treatment of senile functional constipation, can effectively improve clinical symptoms, regulate anxiety and depression, and improve serum gastrointestinal hormones levels, with good curative effect. [ABSTRACT FROM AUTHOR]