DKK3、Wnt/β-连环蛋白信号通路与宫颈癌关系的研究进展.

Cervical cancer is one of the malignant tumors in women, and the pathogenesis and related pathway molecules have been studied more and more deeply. Among them, the research on Wnt/β-catenin signaling pathway has attracted great attention. The Wnt/β-catenin signaling pathway involves a wide range of physiological and pathological processes, including cell growth, differentiation, ontogeny, migration, genetic stability, apoptosis, stem cell self-renewal, and maintenance of adult tissue homeostasis. Stable β-catenin is accumulated in the cytoplasm and transferred to the nucleus, which activates the Wnt/ β-catenin signaling pathway and is one of the inducing factors of multiple cancers. The accumulation of β-catenin occupies a core position in the Wnt/β-catenin signaling pathway. β-catenin drives target genes through Wnt/β-catenin signaling pathway and participates in the multi -step occurrence and development of cervical cancer. DKK3 may inhibit the Wnt/β -catenin signaling pathway by degrading β-catenin, blocking the nuclear transport of β-catenin, and thus become a potential key role in the inhibition of cervical cancer. Therefore, it is particularly important to study the relationship between DKK3, Wnt/β-catenin signaling pathway and cervical cancer. [ABSTRACT FROM AUTHOR]