"On-water" reduction of α-keto amide by Hantzsch ester: A chemoselective catalyst- and additive-free way to α-hydroxy amide.

Authors :: Fang, Zhong-Bing
Yu, Ru-Rong
Hao, Fei-Yue
Jin, Zheng-Neng
Liu, Gu-Yue
Dai, Guo-Liang
Yao, Wu-Bing
Wu, Jia-Shou
Source :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry. Dec2021, Vol. 86, pN.PAG-N.PAG. 1p.
Publication Year :: 2021
Abstract: [Display omitted] An efficient and practical method for chemoselective "on-water" reduction of α-keto amide by Hantzsch ester without using any catalysts and additives was developed. Control experiments indicated that the intramolecular hydrogen bond of α-keto amide was crucial for this transformation. A variety of α-hydroxy amides were prepared in high yields in an environmentally friendly way. [ABSTRACT FROM AUTHOR]

Language :: English
ISSN :: 00404039
Volume :: 86
Database :: Academic Search Index
Journal :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry
Publication Type :: Academic Journal
Accession number :: 153926978
Full Text :: https://doi.org/10.1016/j.tetlet.2021.153524

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