H. pylori effects on ghrelin axis: Preliminary change in gastric pathogenesis.

Ghrelin and its receptors are present in the stomach, suggesting that the ghrelin axis plays an essential role in gastrointestinal complications. This investigation aimed to explore the effects of H. pylori infection and gastritis on serum ghrelin and ghrelin axis gene expression. In this study, we enrolled 68 adult ambulatory people referred for upper gastrointestinal endoscopy. The individuals were classified into three groups based on H. pylori infection and gastritis. Total serum ghrelin and tissue gene expression were tested with ELISA and quantitative RT-PCR, respectively. Serum ghrelin and mRNA expression were significantly lower in H. pylori -positive with gastritis subjects compared with both H. pylori -negative with and without gastritis. Growth hormone secretagogue receptor1a mRNA expression was not different between groups while GHSR1b expression was significantly higher in patients with H. pylori infection and gastritis. We propose the ghrelin axis intermediaries, such as GHSR1b, as a potential clinical target for gastric disorders. • H. pylori cause gastritis and have been identified as a class 1 carcinogen. • The study of the ghrelin axis in subjects at risk of gastric cancer can be helpful. • Serum levels and gastric expression of ghrelin were reduced in H. pylori infection. • GHSR1b gastric expression was increased in H. pylori -positive subjects. [ABSTRACT FROM AUTHOR]