Looking at the bigger PICture: understanding and counteracting the decline of persistent inward currents in older adults.

Keywords: ageing; high-density electromyography; motor neuron; motor unit; neuromodulation EN ageing high-density electromyography motor neuron motor unit neuromodulation 5137 5139 3 12/03/21 20211201 NES 211201 Persistent inward currents in motoneurons: role in normal motor behaviour and age-related cha... The world population is ageing. Motoneuron firing is not solely determined by ionotropic synaptic input, but also by complex factors, such as persistent inward currents (PICs). Thus, ingestion of tryptophan or tryptophan-rich proteins could lead to increases in serotonin synthesis and facilitate PICs in ageing motoneurons. [Extracted from the article]