牙囊干细胞应用于牙及牙周组织再生修复的前景及临床转化价值.

BACKGROUND: As a kind of dental mesenchymal stem cells, dental follicle stem cells have considerable application prospect and clinical transformation value in stem cell therapy and tissue engineering because of their excellent characteristics. OBJECTIVE: To review the basic characteristics of dental follicle stem cells and their latest progress in the field of regeneration and repair of tooth and periodontal complex tissue structure. METHODS: The key words were “dental follicle stem cell, regeneration, tooth, bone, periodontal tissue, tissue engineering, review” in Chinese and English. PubMed, Science direct, Medline, CBM, CNKI, and other databases were retrieved in articles published from 2010 to 2021. Finally, 61 articles were included for analysis and discussion. RESULTS AND CONCLUSION: As dental mesenchymal stem cells, dental follicle stem cells have great application value in the field of oral regenerative medicine, and they have the characteristics of rich sources, multi-directional differentiation, and low immunogenicity. At present, dental follicle stem cells are actively used in the regeneration of periodontal tissue, tissue engineering biological root reconstruction and alveolar bone repair. Their therapeutic potential in other tissue injuries and immune system diseases has been continuously explored in recent years. However, before more in-depth clinical application, how to better regulate the functional mechanism of transplanted dental follicle stem cells and control the immune system response, in order to further optimize the construction methods of teeth and periodontal tissue, is worthy of in-depth research and discussion. [ABSTRACT FROM AUTHOR]