考虑细胞外基质黏弹性行为的细胞黏附力学模型.

The viscoelastic nature of the microenvironment around a cell is critical to cell mechanobiology, and modulates the mechanical feedback between cells and extracellular matrix. However, the mechanisms underlying the ways that cells actively sense and respond to the viscoelastic microenvironment remain elusive. There? fore a molecular clutch model was developed for cell traction to predict the effects of substrate viscoelasticity on the dynamics of focal adhesions connecting the intracellular actin cytoskeleton to the viscoelastic substrate. The model predicts that certain levels of viscoelastic dampings can increase cell tractions on relatively compliant substrates, and this damping reduces cell tractions on relatively stiff substrates. The model predictions are qualitatively consistent well with reported experimental observations. The model offers physical insights into the role of substrate viscoelasticity on cell tractions and cell spreading. [ABSTRACT FROM AUTHOR]