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Surface‒Aerosol Stability and Pathogenicity of Diverse Middle East Respiratory Syndrome Coronavirus Strains, 2012‒2018.
- Source :
-
Emerging Infectious Diseases . Dec2021, Vol. 27 Issue 12, p3052-3062. 11p. - Publication Year :
- 2021
-
Abstract
- Middle East respiratory syndrome coronavirus (MERS-CoV) infects humans and dromedary camels and is responsible for an ongoing outbreak of severe respiratory illness in humans in the Middle East. Although some mutations found in camel-derived MERS-CoV strains have been characterized, most natural variation found across MERS-CoV isolates remains unstudied. We report on the environmental stability, replication kinetics, and pathogenicity of several diverse isolates of MERS-CoV, as well as isolates of severe acute respiratory syndrome coronavirus 2, to serve as a basis of comparison with other stability studies. Although most MERS-CoV isolates had similar stability and pathogenicity in our experiments, the camel-derived isolate C/KSA/13 had reduced surface stability, and another camel isolate, C/BF/15, had reduced pathogenicity in a small animal model. These results suggest that although betacoronaviruses might have similar environmental stability profiles, individual variation can influence this phenotype, underscoring the need for continual global viral surveillance. [ABSTRACT FROM AUTHOR]
- Subjects :
- *MERS coronavirus
*CORONAVIRUS diseases
Subjects
Details
- Language :
- English
- ISSN :
- 10806040
- Volume :
- 27
- Issue :
- 12
- Database :
- Academic Search Index
- Journal :
- Emerging Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 153718905
- Full Text :
- https://doi.org/10.3201/eid2712.210344