Back to Search
Start Over
A prospective cohort evaluation of the sensitivity and specificity of the chest X-ray for the detection of lung cancer in symptomatic adults.
- Source :
-
European Journal of Radiology . Nov2021, Vol. 144, pN.PAG-N.PAG. 1p. - Publication Year :
- 2021
-
Abstract
- <bold>Background: </bold>The accuracy of the chest x-ray (CXR) in the identification of lung cancer amongst symptomatic individuals is uncertain.<bold>Purpose: </bold>To determine the diagnostic accuracy of the CXR for the detection of non-small cell carcinomas (NSCLC) and all primary intrathoracic malignancies.<bold>Methods: </bold>A prospective cohort study of consecutive CXR reports obtained within a primary care open access initiative. Eligibility criteria were symptoms specified by National Institute for Clinical Excellence as indicative of possible lung cancer and age over 50-yrs. A positive test was a CXR which led directly or indirectly to investigation with CT. The reference standards were malignancies observed within a one- or two-year post-test period.<bold>Results: </bold>8,948 CXR outcomes were evaluated. 496 positive studies led to a diagnosis of 101 patients with primary intrathoracic malignancy including 80 with NSCLC. Within two-years, a cumulative total of 168 patients with primary intrathoracic malignancies including 133 NSCLC were observed. The sensitivity and specificity for NSCLC were 76% (95 %CI 68-84) and 95% (95 %CI 95-96) within 1-year and 60% (95 %CI 52-69) and 95% (95 %CI 95-96) within 2-years. The 2-yr positive and negative likelihood ratios were 12.8 and 0.4. The results did not differ for NSCLC compared to all primary malignancies. Within this symptomatic population a negative test reduced the 2-year risk of lung cancer to 0.8%.<bold>Conclusions: </bold>A positive test strongly increases the probability of malignancy whereas a negative test does not conclusively exclude the disease. The findings allow the risk of malignancy following a negative test to be estimated. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 0720048X
- Volume :
- 144
- Database :
- Academic Search Index
- Journal :
- European Journal of Radiology
- Publication Type :
- Academic Journal
- Accession number :
- 153706750
- Full Text :
- https://doi.org/10.1016/j.ejrad.2021.109953