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Kinesin family member 2C promotes hepatocellular carcinoma growth and metastasis via activating MEK/ERK pathway.
- Source :
-
Bioscience, Biotechnology & Biochemistry . Nov2021, Vol. 85 Issue 11, p2241-2249. 9p. - Publication Year :
- 2021
-
Abstract
- The current work was intended to explore the function and mechanism of Kinesin family member 2C (KIF2C) in hepatocellular carcinoma (HCC). In this study, KIF2C expression was at a high level in HCC and indicated poor prognosis. Silencing KIF2C significantly suppressed the proliferation, migration, and invasion in HCC cells. Furthermore, silencing KIF2C markedly decreased the expression of Snail, Vimentin, p-MEK, and p-ERK, but increased E-cadherin expression in HCC cells. Moreover, we also found that MEK/ERK inhibitor U0126 could enhance the impact on cell proliferation, migration, and invasion induced by silencing KIF2C in HCC. On the contrary, MEK/ERK activator PAF could weaken the impact induced by silencing KIF2C in HCC. Thus, our findings indicate that KIF2C can promote the proliferation, migration, and invasion by activating MEK/ERK pathway in HCC. KIF2C promotes HCC cell proliferation, migration, and invasion by activating MEK/ERK pathway, which ultimately promotes HCC growth and metastasis. [ABSTRACT FROM AUTHOR]
- Subjects :
- *HEPATOCELLULAR carcinoma
*KINESIN
*METASTASIS
*CADHERINS
*CELL proliferation
Subjects
Details
- Language :
- English
- ISSN :
- 09168451
- Volume :
- 85
- Issue :
- 11
- Database :
- Academic Search Index
- Journal :
- Bioscience, Biotechnology & Biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 153672894
- Full Text :
- https://doi.org/10.1093/bbb/zbab154