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Long-term prognosis for glaucoma in patients with Posner–Schlossman syndrome.
- Source :
-
Graefe's Archive of Clinical & Experimental Ophthalmology . Dec2021, Vol. 259 Issue 12, p3757-3767. 11p. - Publication Year :
- 2021
-
Abstract
- Background: The aim of this study is to investigate the long-term prognosis for glaucoma in patients with Posner–Schlossman syndrome (PSS). Methods: In this retrospective case series study, a total of 98 patients with PSS from January 2014 to February 2019 were included in this study. Initial presentations and follow-up data were obtained from medical records. Vision-related quality of life (VR-QoL) was assessed using the 25-item National Eye Institute Visual Functioning Questionnaire. Results: Of the 98 patients included in the study, 66 (67%) presented with glaucoma, and among them, 21 (32%) required glaucoma surgery. The mean follow-up time was 50.1 months (range 1–263 months). Iris involvement was noted in 46 (46.9%) eyes; 26 (26.5%) had sectoral iris changes and 20 (20.4%) showed diffuse iris changes. Eyes with iris involvement had a significantly higher number of acute attacks of uveitis than those without (p = 0.010). The 5-year glaucoma surgery-free interval was 77.8% according to Kaplan–Meier analysis. Significant predictors of glaucoma surgery included iris involvement (hazard ratio [HR] = 5.215; confidence interval [CI] = 1.387–19.610), highest number of anti-glaucoma agents (HR = 5.069; CI = 1.848–13.905), baseline average retinal nerve fiber layer thickness (RNFLT) thickness (HR = 0.949; CI = 0.917–0.982), and disease duration (HR = 0.977; CI = 0.957–0.996). Overall complete surgical success and qualified success at 2 years was 35.3% and 75.5%, respectively. Patients with iris involvement, glaucoma surgery, and thinner average RNFLT had significantly poorer VR-QoL (all, p < 0.05). Conclusions: Patients with PSS and glaucoma required glaucoma surgery in a high rate. Iris involvement increased the probability of surgical treatment and lowered the VR-QoL of PSS patients. [ABSTRACT FROM AUTHOR]
- Subjects :
- *PROGNOSIS
*GLAUCOMA
*IRIS (Eye)
*QUALITY of life
*NERVE fibers
Subjects
Details
- Language :
- English
- ISSN :
- 0721832X
- Volume :
- 259
- Issue :
- 12
- Database :
- Academic Search Index
- Journal :
- Graefe's Archive of Clinical & Experimental Ophthalmology
- Publication Type :
- Academic Journal
- Accession number :
- 153556081
- Full Text :
- https://doi.org/10.1007/s00417-021-05291-0