TSC1 loss increases risk for tauopathy by inducing tau acetylation and preventing tau clearance via chaperone-mediated autophagy.

The article focuses on TSC1 loss increases risk for tauopathy by inducing tau acetylation and preventing tau clearance via chaperone-mediated autophagy. Topics include the age-associated neurodegenerative disorders demonstrating tau-laden intracellular inclusions are known as tauopathies, the linked a loss-of-function mutation in the TSC1 gene to tau accumulation lobar degeneration, and the genetic variants in TSC1 that decrease TSC1/hamartin levels and predispose to tauopathies.