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Two new scopadulane diterpenoids from Scoparia dulcis attenuated palmitate-induced viability in MIN6 cells.
- Source :
-
Fitoterapia . Nov2021, Vol. 155, pN.PAG-N.PAG. 1p. - Publication Year :
- 2021
-
Abstract
- Two new scopadulane diterpenoids, termed Scopadulcic acids D (1, SDD) and E (2, SDE), together with two known analogues (3 and 4) were isolated from Scoparia dulcis. Their structures were elucidated by comprehensive spectroscopic analysis. The absolute configurations of 1 and 2 were determined by calculated electronic circular dichroism (ECD). Meanwhile, X-ray crystallographic analysis was applied to determine the absolute configuration of 1. All compounds were tested for their effect on attenuating palmitate-induced viability at the concentrations of 25 and 50 μM. The results showed that they significantly attenuated the palmitate-induced viability in MIN6 cells. [Display omitted] [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 0367326X
- Volume :
- 155
- Database :
- Academic Search Index
- Journal :
- Fitoterapia
- Publication Type :
- Academic Journal
- Accession number :
- 153496215
- Full Text :
- https://doi.org/10.1016/j.fitote.2021.105051