Back to Search
Start Over
Thermoresponsive chimeric nanocarriers as drug delivery systems.
- Source :
-
Colloids & Surfaces B: Biointerfaces . Dec2021, Vol. 208, pN.PAG-N.PAG. 1p. - Publication Year :
- 2021
-
Abstract
- Chimeric or mixed nanosystems belong to the class of advanced therapeutics. Their distinctive characteristic compared with other types of nanoparticles is that they combine two or more different classes of biomaterials. These platforms have created a promising and versatile field of nanomedicine, incorporating materials that are biocompatible, such as lipids, but also functional, such as stimuli-responsive polymers. In the present work, thermoresponsive chimeric nanocarriers composed of l -α-phosphatidylcholine (Egg, Chicken) (EPC) phospholipids and poly(N-isopropylacrylamide)-b-poly(lauryl acrylate) (PNIPAM-b-PLA) block copolymers were designed and developed. Initially, model lipid bilayers with incorporated polymers and drug molecule TRAM-34 were built and studied for their thermodynamics, in order to assess the stability and functionality of the systems. Chimeric nanoparticles of EPC and PNIPAM-b-PLA were then developed and evaluated for their physicochemical properties in different medium conditions, as well as for their morphology. Polymer incorporation led to alterations in the properties and morphology of the nanoparticles, while interactions with serum proteins were absent. TRAM-34 was also incorporated inside the developed nanocarriers, followed by incorporation and release studies, which revealed the functionality of the system in elevated temperature conditions. Finally, in vitro studies on normal cells suggest the biocompatibility of these nanosystems. The proposed platforms are promising for further studies and applications in vitro and in vivo. [Display omitted] • Thermoresponsive chimeric nanocarriers with incorporated TRAM-34 were developed. • The thermotropic behavior of DPPC membranes is affected by PNIPAM-b-PLA and TRAM-34. • PNIPAM-b-PLA polymer stabilizes the membrane and leads to homogeneous nanoparticles. • EPC:PNIPAM-b-PLA nanocarriers release TRAM-34 in response to elevated temperature. • EPC:PNIPAM-b-PLA nanocarriers are biocompatible with HEK-293 cells. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09277765
- Volume :
- 208
- Database :
- Academic Search Index
- Journal :
- Colloids & Surfaces B: Biointerfaces
- Publication Type :
- Academic Journal
- Accession number :
- 153477506
- Full Text :
- https://doi.org/10.1016/j.colsurfb.2021.112141