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inflammatory role of silent urate crystal deposition in intercritical gout.

Authors :
Diaz-Torne, Cesar
Ortiz, M Angels
Garcia-Guillen, Andrea
Jeria-Navarro, Sicylle
Sainz, Lluís
Fernandez-Sanchez, Susana
Corominas, Hector
Vidal, Silvia
Source :
Rheumatology. Nov2021, Vol. 60 Issue 11, p5463-5472. 10p.
Publication Year :
2021

Abstract

Objective To study subclinical inflammation in intercritical gout patients and its relation to the estimated size of monosodium urate crystal deposition and cardiovascular risk factors. Methods We performed a secretome analysis and the quantification of cytokine and adipokine plasma levels [IL-1β, IL-18, IL-6, soluble IL-6 receptor (sIL-6R), TNF-α, C-X-C motif chemokine 5, RANTES (Regulated upon Activation, Normal T Cell Expressed and Presumably Secreted), leptin, resistin and adiponectin] to analyse subclinical inflammation in intercritical gout patients. Since it is currently not feasible to determinate the whole body deposit of monosodium urate crystals, we created an indirect clinical classification to estimate it. Then we compared cytokine levels in controls and gout patients and in patients with different crystal deposition sizes. We also studied the association between cytokine-levels and the number of cardiovascular risk factors. Results Ninety consecutive patients attending a crystal arthritis unit were studied. IL-18, sIL-6R, RANTES, leptin and adiponectin were higher in intercritical gout patients than in controls. An association was observed between IL-18, sIL6-R and RANTES levels and the size of crystal deposition. IL-18, sIL6-R, RANTES and leptin were higher in patients with no cardiovascular risk factors compared with controls with no risk factors. Conclusion Our results showed that the levels of some pro-inflammatory cytokines and metabolic proteins are elevated in intercritical gout patients. The levels of certain cytokines were related to the estimated size of the monosodium urate crystal deposition and to the number of cardiovascular risk factors. These cytokine changes may help to explain the increase in cardiovascular events in gout patients. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
14620324
Volume :
60
Issue :
11
Database :
Academic Search Index
Journal :
Rheumatology
Publication Type :
Academic Journal
Accession number :
153476438
Full Text :
https://doi.org/10.1093/rheumatology/keab335