慢性鼻病中乏氧诱导因子与 5-脂加氧酶表达变化及其与疾病严重程度关系研究.

Objective: To explore the changes in the expression of hypoxia-inducible factor (HIF-1α) and 5-lipoxygenase (5-LOX) in chronic nasal diseases and their relationship with the severity of the disease. Methods: From July 2019 to November 2020, 75 patients with chronic rhinopathy admitted to our hospital were selected as the research subjects; among them, 25 were nasal polyps, 25 were allergic rhinitis, and 25 were sinusitis; 30 cases of transnasal septum were selected during the same period. The inferior turbinate mucosal tissue of patients undergoing inferior turbinoplasty with curvature correction was set as the control group. Compare the levels of hypoxia-inducible factor and 5-lipoxygenase protein and mRNA in the four groups of patients; and analyze the correlation between HIF-1α and 5-LOX in different nasal diseases. Results: The expression levels of HIF-1α and 5-LOX in the nasal polyp group, allergic rhinitis group, and sinusitis group were higher than those in the control group (P<0.05); HIF-1α in the nasal polyp group, allergic rhinitis group, and sinusitis group The expression level of 5-LOX was not statistically significant (P>0.05). The expression levels of HIF-1α and 5-LOX mRNA in the nasal polyp group, allergic rhinitis group, and sinusitis group were higher than those in the control group (P<0.05); HIF- in the nasal polyp group, allergic rhinitis group, and sinusitis group The expression levels of 1α and 5-LOX mRNA were not statistically significant (P>0.05). Parman correlation analysis showed that HIF-1α protein expression was positively correlated with 5-LOX protein expression in different nasal diseases (P<0.05). Conclusion: In chronic nasal diseases (nasal polyps, allergic rhinitis, sinusitis), the expression levels of HIF-1α and 5-LOX are significantly increased, and they may promote and influence each other in the development of chronic diseases. [ABSTRACT FROM AUTHOR]