A Novel Coumarin-based Fluorescent Probe with Aggregation Induced Emission for Detecting CN− and its Applications in Bioimaging.

Although cyanogen ion (CN−) plays important role in industry which also bring acute environmental pollution. More serious, trace CN− enters the human body can cause serious consequences and even death. Therefore, it is of great significance to detect trace CN− with high sensitivity. Herein, a novel aggregation-induced emission (AIE) probe C-BH was synthesized based on coumarin matrix. Probe C-BH showed high selectivity and sensitivity toward CN− by dual channel response due to the excited state intramolecular proton transfer (ESIPT). The low detection limit was calculated to be 0.05 µM. Moreover, probe C-BH was successfully used for imaging CN− in living cells and zebrafish due to its low toxicity and excellent optical properties. [ABSTRACT FROM AUTHOR]