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Investigation of gene–environment interactions in relation to tic severity.
- Source :
-
Journal of Neural Transmission . Nov2021, Vol. 128 Issue 11, p1757-1765. 9p. - Publication Year :
- 2021
-
Abstract
- Tourette syndrome (TS) is a neuropsychiatric disorder with involvement of genetic and environmental factors. We investigated genetic loci previously implicated in Tourette syndrome and associated disorders in interaction with pre- and perinatal adversity in relation to tic severity using a case-only (N = 518) design. We assessed 98 single-nucleotide polymorphisms (SNPs) selected from (I) top SNPs from genome-wide association studies (GWASs) of TS; (II) top SNPs from GWASs of obsessive–compulsive disorder (OCD), attention-deficit/hyperactivity disorder (ADHD), and autism spectrum disorder (ASD); (III) SNPs previously implicated in candidate-gene studies of TS; (IV) SNPs previously implicated in OCD or ASD; and (V) tagging SNPs in neurotransmitter-related candidate genes. Linear regression models were used to examine the main effects of the SNPs on tic severity, and the interaction effect of these SNPs with a cumulative pre- and perinatal adversity score. Replication was sought for SNPs that met the threshold of significance (after correcting for multiple testing) in a replication sample (N = 678). One SNP (rs7123010), previously implicated in a TS meta-analysis, was significantly related to higher tic severity. We found a gene–environment interaction for rs6539267, another top TS GWAS SNP. These findings were not independently replicated. Our study highlights the future potential of TS GWAS top hits in gene–environment studies. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 03009564
- Volume :
- 128
- Issue :
- 11
- Database :
- Academic Search Index
- Journal :
- Journal of Neural Transmission
- Publication Type :
- Academic Journal
- Accession number :
- 153184382
- Full Text :
- https://doi.org/10.1007/s00702-021-02396-y